EpistaBase

Episteme - intellectually certain knowledge

Science is becoming agentic. Researchers direct AI systems to search literature, write code, analyse data and propose experiments. But current systems are blind to the experimental record: the raw data, protocols, analyses, and decisions that show not only what a lab discovered, but how it got there. We believe whoever builds this system of record will become the default interface between scientists who operate in the physical world and their agentic counterparts operating in the digital world.

The volume of biological data for R&D is growing rapidly and has already outgrown the tools used to manage it. Today, data moves across proprietary software, desktop tools, spreadsheets, shared drives and slide decks. These tools help scientists complete individual tasks, but structure and provenance are lost at every handoff. This results in fragmented evidence that executives, scientists, and agents cannot reliably query, reuse or act on.

EpistaBase is the full-stack, science-native platform that turns the research workflow itself into a governed, shared experimental record. Raw instrument data is analysed on the same sovereign infrastructure that stores it, so every output remains connected to its source, with governance, versioning and provenance built in. This gives organisations and their agents a trusted foundation for querying, reusing and acting on experimental evidence. The more experiments that pass through EpistaBase, the more valuable the organisation’s scientific memory becomes.

EpistaBase is the governed, science-native data and compute infrastructure upon which agent-driven research will be built.

Who we are

EpistaBase is built by researchers and engineers who have taken AI infrastructure, systems and tools from frontier research into enterprise production and clinical evaluation.

McClain Thiel

McClain builds production agentic AI systems with Databricks and researches language-model post-training for biological sequence design at UCL. Previously, he led generative-AI work at Snorkel AI and Tempus and is an Encode AI for Science Fellow.

Profile
Will Bolton

Will works at the intersection of AI and science. He was an Encode AI for Science Fellow at Oxford working with Professor Philip Torr and obtained his PhD from Imperial College London. His work has appeared in journals such as Nature Machine Intelligence and The Lancet Digital Health, as well as leading AI conferences.

Profile